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- New DataFrames and Document Intelligence advancements enable mathematically precise, enterprise-scale data processing that transforms how companies automate their most critical workflows.
- This latest edition simplifies complex analysis and data tasks for analysts, lowering adoption barriers through AI-guided configuration and natural language automation.
ATLANTA, GA — November 4, 2025 – Sema4.ai, the enterprise AI agent company, today announced breakthrough data innovations in its next-generation Enterprise AI Agent Platform, introducing DataFrames, Document Intelligence, enhanced Worker Agents with advanced reasoning architecture, and enhanced Agent Studio. These data-centric advancements address the fundamental accuracy and reliability challenges that have limited enterprise AI adoption, enabling organizations to automate complex, multi-step data workflows with unprecedented precision and consistency.
According to Gartner, the adoption of AI agents by enterprises is accelerating at a historic pace. By 2026, 40% of enterprise applications will feature integrated task-specific agents, up from less than 5% today. However, enterprises have struggled with LLM’s mathematical unreliability and inability to handle large-scale data processing. Sema4.ai‘s new data handling capabilities eliminate these barriers, delivering the accuracy, precision and deterministic outcomes at the enterprise-scale needed to automate mission-critical workflows with complete confidence.
Innovative agent-based data engineering architecture
At the core of the platform is an innovative approach to data processing that combines advanced reasoning models (GPT-5, o3, o4-mini, and Claude 4.5) with mathematically precise SQL processing. This architecture enables agents to understand context and meaning through LLMs while performing all calculations and data operations with 100% mathematical accuracy—eliminating the hallucinations and calculation errors that have made traditional AI unsuitable for enterprise-critical processes.
New innovations include:
- DataFrames: mathematical accuracy and precision at enterprise scale. DataFrames end the hours of tedious manual work analysts spend comparing data across Excel files, databases, and enterprise systems. DataFrames revolutionizes enterprise data analysis by serving as the agent’s intelligent data workspace, enabling mathematically accurate and precise processing of millions of rows without the context limitations and calculation errors that plague traditional AI tools. Unlike LLM-based analysis that consumes expensive tokens and produces unreliable mathematical results, DataFrames processes data locally using SQL for complete accuracy and auditability.
- Document Intelligence: from documents to agent-ready data: Document Intelligence eliminates the manual document processing bottlenecks that consume hours of analyst time and delay critical business decisions. Powered by industry-leading multi-pass agentic processing, Document Intelligence transforms any document into structured, agent-ready DataFrames with near-perfect accuracy. The breakthrough AI-guided configuration enables business users to teach the system once, then automatically adapt to document variations across 100+ languages and file types.
- Enhanced Worker Agents: 24/7 autonomous automation. New Worker Agent capabilities help break the reactive cycle of waiting for humans to monitor and respond to enterprise events—emails, service tickets, database changes, and system alerts that pile up overnight and during off-hours. Building on proven autonomous processing capabilities, enhanced Worker Agents now connect to any enterprise event via the new Work Item API, enabling unattended automation of complex multi-step workflows. These agents combine the mathematical precision of DataFrames with document understanding capabilities to handle end-to-end business processes with enterprise-grade reliability.
- Enhanced Agent Studio: accelerate agent creation: Business users are further empowered to create accurate agents for complex workflows. New capabilities accelerate agent development for both business users and developers by eliminating the complexity that traditionally requires extensive technical expertise. Studio now includes our new AI agent architecture enhanced for advanced reasoning models, delivering more consistent execution than using LLMs directly. Sai, our AI-powered guide for agent creation, is now integrated into our runbook editor to help users build runbooks step-by-step, while leveraging its existing capabilities for quick agent creation and configuration. Combined with an intuitive new user experience, Studio empowers business users to build agents using plain English while providing developers with the advanced tools and flexibility they need for sophisticated integrations.
Empowering business users with enterprise-grade data capabilities
Sema4.ai’s progressive approach eliminates traditional technical barriers with LLMs like inaccurate calculations, limited context windows, and costs associated with using tokens to process large datasets. Business users can now perform sophisticated data engineering work through natural language instructions—joining, cleaning, enriching, and analyzing data automatically—while the platform handles complex transformations with mathematical accuracy.
With DataFrames, most data operations on Excel and CSV files no longer require custom SQL development. Business users can reconcile data across multiple sources, perform complex analysis, and generate insights through conversational interfaces, while maintaining the precision and auditability that enterprise operations demand.
“With this release, we are delivering enterprise AI agents that organizations can trust for their most critical data workflows,” said Rob Bearden, CEO and Co-founder of Sema4.ai. “Our breakthrough data capabilities eliminate the gaps in accuracy that have prevented enterprises from automating their most valuable processes. From multi-source data reconciliation to complex document processing workflows, Sema4.ai provides the mathematical precision, enterprise scale, and deterministic outcomes businesses need to automate work that truly moves the needle.”
Sema4.ai: delivering measurable results at scale
Since launching its Enterprise AI platform last year, Sema4.ai has helped Fortune 500 companies automate more than 80% of the work within their deployed use cases from invoice reconciliation, regulatory compliance, contract processing and more. Sema4.ai Agents enable Koch companies to automate manual reconciliation processes that are traditionally time-consuming, error-prone, and resource-intensive. By parsing and understanding hundreds of invoices line by line and integrating with existing financial systems, the agents automate the entire workflow, reducing costs, strengthening controls, and saving hours or even days of work.
“By integrating Sema4.ai’s AI agents into our operations, we are setting a new standard for productivity and operational excellence,” said Matt Hoag, Chief Technology Officer at Koch. “This collaboration enhances our internal workflows and positions us to offer innovative solutions to other enterprises seeking to leverage AI for transformative results.”
The news follows several major milestones for Sema4.ai, including the general availability of Team Edition on Snowflake Marketplace and a $25 million Series A extension, which brings the total Series A funding to $55.5 million. Sema4.ai has also expanded its reach through new partnerships, including Rackspace, and added availability on AWS Marketplace and integrations with Docker’s MCP Gateway, further strengthening its mission to build, deploy, and manage SAFE (secure, accurate, fast, and explainable) enterprise AI agents at scale.
“Sema4.ai is advancing what’s possible with enterprise AI,” said Kieran Kennedy, VP, Data Cloud Product Partners, Snowflake. “By combining Sema4.ai Agents with Snowflake’s secure and scalable data foundation, joint customers are discovering new ways to automate complex workflows and gain deeper insights from their data. Together, enterprises can build a trusted, data-driven foundation for the next era of AI innovation.”
The Sema4.ai Enterprise AI Agent Platform is available now. For more information or to schedule a demo, visit https://sema4.ai.
About Sema4.ai
Sema4.ai believes enterprise AI agents are the “killer app” of the AI era—revolutionizing how knowledge work is executed. Our full lifecycle enterprise AI platform enables businesses to build, run, and manage AI agents at scale. Our platform was designed from the ground up to deliver SAFE AI agents that are secure, accurate, fast, and extensible. And, unlike other agentic offerings, our agents enable the business user to define the process and the best practice outcomes.
By empowering business people, and not just developers, to build and deploy AI agents that understand context, reason, and act autonomously, Sema4.ai is transforming how work gets done in the enterprise. This approach to agentic automation is driving significant gains in operational efficiency, productivity, and cost savings for some of the world’s largest and most successful companies.
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